早期发病的消化不良预测了多个系统缩的短生存期
Takahide Wada1, Toshio Shimizu2, Yuri Asano2
1Department of Neurology, Tokyo Metropolitan Neurological Hospital (TMNH), 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan. takahide_wada@outlook.jp.
Journal of neurology
|August 19, 2024
概括
发病后三年内出现症状性消化不良预测多个系统缩 (MSA) 患者的生存时间较短. 这影响了MSA-大脑动症 (MSA-C) 和MSA-帕金森症 (MSA-P) 亚型.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 退行性疾病 退行性疾病
背景情况:
- 在多个系统缩 (MSA) 中,食障碍的预后影响受到辩论.
- 调查MSA的消化不良严重程度和生存率至关重要.
- 需要区分MSA亚型 (MSA-C和MSA-P) 之间的影响.
研究的目的:
- 确定MSA中失消症严重程度和存活率之间的关系.
- 评估食障碍对生存的影响是否在MSA-C和MSA-P之间有所不同.
- 为了确定失症作为MSA的预后因素.
主要方法:
- 对297名MSA患者的回顾性分析 (MSA-C: 171,MSA-P: 126).
- 在发病后3年内使用Hyodo评分通过FEES评估症状性消化不良.
- 使用日志等级和考克斯比例危险模型进行生存分析.
主要成果:
- 发病后3年内出现的症状性消化不良与较短的存活时间 (4.2岁与7.3岁相比) 有关.
- 在多变量分析中,在3年内出现的消化障碍独立预测了更短的生存期.
- 在MSA-C和MSA-P中,Hyodo得分与生存相关,尽管MSA-P的得分更高.
结论:
- 早期症状性消化不良 (3年内) 是MSA生存率降低的重要预测因素.
- 通过Hyodo评分评估的缺食症严重程度,对MSA-C和MSA-P的生存率产生影响.
- 这些发现突出显示,食障碍是MSA管理中的关键预后标志物.
相关概念视频
Barrett Esophagus-I: Introduction
78
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
78
Esophageal Strictures-II: Clinical Features and Management
57
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
57
Myasthenia Gravis: Diagnostic Tests
714
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
714
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
94
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
94
Barrett Esophagus-II: Clinical Manifestations and Management
131
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
131
Myasthenia Gravis: Overview and Treatment
1.3K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.3K


