非药物干预和成人表观遗传衰老:范围审查协议
Alina Liebich1, Shenglin Zheng2,3, Theresa Schachner4
1School of Medicine, University of St. Gallen, St.Gallen, Switzerland.
PloS one
|August 19, 2024
概括
本范围审查确定了可能减缓表观遗传衰老的非药物干预措施. 它综合了有关干预组件和交付模式的证据,以指导健康老龄化策略和减少疾病负担.
科学领域:
- 老年学和公共卫生
背景情况:
- 老龄化是慢性疾病和非传染性疾病 (NCD) 的首要危险因素.
- 非药物干预可以减轻非传染性疾病和减缓生物衰老,这是表观遗传钟所表明的.
- 缺乏对影响表观遗传衰老的干预措施的全面概述.
研究的目的:
- 识别和评估针对表观遗传衰老的非药物干预措施.
- 综合健康老龄化倡议的干预组件和交付方式.
- 减少非传染性疾病 (NCD) 和常见精神疾病 (CMD) 的社会负担.
主要方法:
- 对成人 (≥18岁) 表观遗传衰老的干预研究进行范围审查.
- 搜索了五个数据库 (2011年7月至2023年12月) 的RCT,非随机对照研究,队列和病例对照研究.
- 使用CASP检查清单评估研究质量,并提取了有关干预组件和表观遗传结果的数据.
主要成果:
- 本部分应在审查完成后填写.
结论:
- 本综述将总结针对表观遗传衰老的非药物干预措施.
- 它将确定未来研究的关键干预组件和交付模式.
- 这些发现将指导健康衰老策略,并减少NCD/CMD负担.
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