相关实验视频

Updated: Jun 16, 2025

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Published on: May 25, 2022

白天的时间会影响心肌细胞收缩率的MrgD-依赖调节

André L L Monteiro^1,2, Marcos Eliezeck¹, Sérgio R A Scalzo¹

¹Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

American journal of physiology. Cell physiology

|August 19, 2024

概括

阿拉曼丁 (ALA) 根据每天的时间不同地影响心脏细胞收缩,影响心血管平衡和潜在的未来心脏疗法.

科学领域:

心血管生理学心血管生理学
时间生物学时间生物学
分子药理学分子药理学

背景情况:

氨酸- ангиотензин系统 (RAS) 对于心血管平衡至关重要,涉及诸如 ангиотензин-II 和 ангиотензин-1-7 等关键.
阿拉曼丁 (ALA),结构上类似于血管素-(1-7),通过与Mas相关的G蛋白结合受体成员D (MrgD) 增强心肌细胞收缩性.

研究的目的:

调查阿拉曼丁 (ALA) 对心肌细胞收缩性的影响是否表现出一天中的时间变化.
探索与Mas相关的G蛋白结合受体成员D (MrgD) 和氧化 (NO) 在ALA的时调作用中的作用.

主要方法:

心肌细胞收缩性在小鼠中被评估在四个不同的Zeitgeber时间 (ZTs).
使用了药理学剂,包括一个MrgD激动剂 (β-alanine) 和一个NO合成酶抑制剂 (N-nitro-l-arginine甲基).
测量了ALA对心肌细胞缩短的影响,测量了光暗周期的不同阶段.

主要成果:

在光相 (ZT2) 期间,ALA增强了心肌细胞缩短,这取决于MrgD信号,并与氧化 (NO) 生产相关.
在黑暗阶段 (ZT14),ALA负调节心肌细胞收缩.
在ZT8和ZT20中没有观察到ALA对肌细胞缩短的显著影响,这表明了特定的时间效应.

结论:

心肌细胞中的阿拉曼丁 (ALA) /MrgD信号受到显著的时间调制,根据一天中的时间对收缩性表现出相反的影响.
这些发现强调了昼夜计时在ALA的心血管作用中的重要性.
结果表明,结合昼夜节律调节与针对RAS的药物治疗心脏病的慢性治疗的潜力.

关键词:

阿拉曼迪因 (Alamandine) 是一种药物.分数缩短的部分缩短.心灵的心灵心灵的心灵心灵的心灵心灵灯光/黑暗周期的周期.氧化氧化是一种氧化.

更多相关视频

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Published on: December 16, 2022

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

相关概念视频

Pathophysiology of Cardiac Performance

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

G-Protein Gated Ion Channels

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...