型Dx复发率和PREDICT估计在早期乳腺癌中的相关性:一个单一机构的经验
Ezzeldin M Ibrahim1, Bushra A Al-Quzi2, Ahmed Y Shaheen2
1Oncology Department, King's College London-Jeddah, Jeddah, Kingdom of Saudi Arabia.
JCO global oncology
|August 19, 2024
概括
瘤型Dx复发率评分 (RS) 和PREDICT工具在估计早期乳腺癌患者化疗益处方面显示出显著的不一致. 在预测辅助化疗效益方面,PREDICT不能取代RS.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 瘤型Dx复发率评分 (RS) 是激素受体阳性 (HR+),人体表皮生长因子受体2-阴性 (HER2-) 早期乳腺癌的关键预后和预测工具.
- RS 测试的成本可能是一个障碍,促使人们对像 PREDICT 工具这样的可访问替代品感兴趣.
研究的目的:
- 评估型Dx复发得分 (RS) 与PREDICT工具对辅助化疗效益的估计之间的相关性.
- 评估这两种方法在预测早期乳腺癌治疗结果方面的一致性.
主要方法:
- 对112名HR+,HER2早期乳腺癌患者的回顾性审查.
- 使用斯皮尔曼等级和麦克内马尔测试,分析RS值与PREDICT工具估计之间的相关性.
主要成果:
- 在绝对RS值和PREDICT预测的化疗益处之间发现了显著的正相关性.
- 在基于RS和基于PREDICT的风险分配之间观察到高不一致率 (48-67%).
- 在两种方法之间的化疗效益百分比方面没有发现显著的相关性.
结论:
- 在预测HR+,HER2-早期乳腺癌的辅助化疗效益方面,RS和PREDICT工具之间存在显著的不一致.
- 在指导化疗决策时,PREDICT工具不能代替RS.
- 需要进一步的研究,以优化精准医学在乳腺癌管理.
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