在喘病毒性恶化期间和健康小鼠中,类固醇对微生物组的修改
Kazuma Yagi1, Alexander D Ethridge2, Nicole R Falkowski3,4
1Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States.
概括
对喘恶化的肺部类固醇治疗改变了肺部和肠道微生物群,影响了免疫反应和代谢物. 早期的类固醇使用可能会影响随后的病毒诱导疾病严重程度.
科学领域:
- 免疫学和微生物学
- 药理学和药物发现
- 呼吸系统医学 呼吸系统医学
背景情况:
- 病毒感染加剧了喘,导致呼吸道炎症增加和粘液产生.
- 肺部类固醇治疗,如流他,用于控制喘,但它们对微生物群的影响尚未完全理解.
- 病毒恶化,类固醇治疗和喘中的宿主微生物群之间的相互作用需要进一步调查.
研究的目的:
- 为了研究喘病毒性恶化如何影响肺部和肠道微生物群以及免疫反应.
- 确定流他对宿主代谢的影响及其与微生物组变化的关系.
- 评估先发性流动治疗对宿主对病毒感染和相关微生物组变化的反应的影响.
主要方法:
- 动物中的过敏喘模型接受了呼吸道同胞病毒 (RSV) 感染,有或没有流动 (FLUT) 治疗.
- 使用元基因组测序分析了肺部和肠道微生物组合.
- 测量了血中的代谢物概况,并使用PICRUSt2软件分析了微生物组的预测代谢途径.
主要成果:
- 西治疗减少了RSV诱导的气道过敏反应和粘液,但增加了IL-17的表达.
- RSV恶化和流动治疗显著改变了肺部和肠道微生物组合.
- 代谢分析显示了血代谢物的治疗特异性变化,反映了宿主和微生物的贡献.
- 在原始动物中,先发制药性流动治疗导致疾病严重程度的增加,微生物组的改变,以及不同的代谢概况.
结论:
- 肺部类固醇治疗在病毒性喘恶化期间会影响微生物组和代谢组.
- 弗卢蒂卡松会影响局部的肺部和全身粘膜微生物组,并可能导致疾病.
- 受到类固醇治疗影响的病毒恶化期间微生物组和代谢组的变化可能会影响疾病的发展轨迹.
- 早期的肺性类固醇暴露可能通过微生物组调节影响随后的病毒诱导疾病.
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:29Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K