长期等待长期作用的HIV预防和治疗配方
Willem Daniel Francois Venter1, Monica Gandhi2, Simiso Sokhela3
1Wits Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Public Health Medicine, School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Johannesburg, South Africa.
The lancet. HIV
|August 19, 2024
概括
新的长效药物在预防和治疗艾滋病毒方面表现出高效. 迫切需要全球协调行动,以确保公平的机会,特别是在低收入国家,以实现艾滋病毒消除目标.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 大规模的随机研究证实了新型长效药物在预防和治疗艾滋病毒方面的高效性和可接受性.
- 建模研究表明,这些药物对于实现艾滋病毒消除目标至关重要.
- 目前获得这些创新治疗方法的机会有限,特别是在艾滋病毒流行率高的低收入和中等收入国家 (LMICs).
研究的目的:
- 突出协调利益相关者行动的关键需要,以促进市场进入和公平获得长效艾滋病毒病原体.
- 强调如果不立即采取行动,实现全球艾滋病毒目标的潜在延迟.
主要方法:
- 对长效艾滋病毒药物的现有研究和建模研究的分析.
- 审查当前的访问挑战和实施项目控制.
- 与成功的药物引入策略进行比较分析,例如dolutegravir.
主要成果:
- 尽管有效性已被证明,但长效艾滋病毒药物的获取受到限制,原始制药公司控制着研究和实施.
- 在LMICs中,进入市场的协调特别低,危及UNAIDS的全球目标.
- 如果没有协调的努力,广泛的访问可能会被推迟到2030年代.
结论:
- 世卫组织,财政捐助者,制造商和政府之间的紧急协调行动对于全球消除艾滋病毒至关重要.
- 对于长效的艾滋病毒病原体,建议采用类似于成功引入多卢特格拉维尔的策略.
- 由于已确立的全球艾滋病毒目标和这些新药的潜力,延迟获取是不可接受的.
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