Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

2.4K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.4K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

5.8K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
5.8K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Structural Protein Function01:56

Structural Protein Function

27.5K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
27.5K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.1K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.1K
Fibrous Proteins00:55

Fibrous Proteins

2.1K
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

ACS chemical biology·2026
Same author

Fibrillin-1 Inhibits Early Adipogenic Commitment Via αvβ3 Integrin Signaling.

Journal of molecular biology·2026
Same author

Corrigendum to "Tissue material properties, whole-bone morphology and mechanical behavior in the <i>Fbn1</i> <sup>C1041G/+</sup> mouse model of Marfan Syndrome" [Matrix Biol. Plus 23 (2024) 100155].

Matrix biology plus·2025
Same author

Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae.

Acta biomaterialia·2025
Same author

Double-Edged Signaling: FAK's Role in Aortic Dissection Progression.

JACC. Basic to translational science·2025
Same author

Exploring thoracic aorta ECM alterations in Marfan syndrome: insights into aorta wall structure.

Scientific reports·2025
Same journal

Airway macrophage specific glycocalyx expression and remodeling following viral infection.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Cartilage intermediate layer protein (CILP) in cardiac fibrosis: Protective or pathogenic?

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Polymerizing laminins: Assembly, functions and disorders.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Oligodendrocyte integrin-β1 regulates blood-brain barrier and remyelination in hemorrhagic brain.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Dynamic regulation of the tissue microenvironment by integrins and the extracellular matrix.

Matrix biology : journal of the International Society for Matrix Biology·2026
Same journal

Corrigendum to "Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro" [Matrix Biology 146 (2026) 102008].

Matrix biology : journal of the International Society for Matrix Biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 16, 2025

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.2K

纤维肌菌素异型促进产后骨发育.

Neha E H Dinesh1, Nissan Baratang2, Justine Rosseau2

  • 1Faculty of Medicine and Health Sciences, Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.

Matrix biology : journal of the International Society for Matrix Biology
|August 19, 2024
PubMed
概括
此摘要是机器生成的。

纤维蛋白 (FN) 对于骨发育至关重要. 细胞 (cFN) 和血 (pFN) 异形都对体生成,软骨成熟和骨形成至关重要,影响整体生长.

关键词:
冠状细胞 (chondrocytes) 是一种细胞.混凝土生成 (chondrogenesis) 是一种不同化的差异化纤维纤维素的生长方式增长板是指增长板.骨的发展 骨的发展

更多相关视频

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat
09:49

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat

Published on: June 9, 2021

5.9K
Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

7.0K

相关实验视频

Last Updated: Jun 16, 2025

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

8.2K
Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat
09:49

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat

Published on: June 9, 2021

5.9K
Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

7.0K

科学领域:

  • 生物化学 生物化学
  • 发展生物学 发展生物学
  • 整形外科 整形外科 整形外科

背景情况:

  • 纤维蛋白 (FN) 是一种细胞外基质糖蛋白,对组织发育至关重要.
  • 在FN的突变与脊髓甲基细胞失生症有关,突出其在骨健康中的作用.
  • 在骨发育中FN异型的特定作用仍然在很大程度上没有特征.

研究的目的:

  • 研究细胞FN (cFN) 和血FN (pFN) 异型在骨发育中的功能重要性.
  • 阐明cFN和pFN在软体生成和骨形成中的不同和联合作用.
  • 为了确定在骨生长过程中由FN调节的分子通路.

主要方法:

  • 条件淘汰赛小鼠模型的生成:cFNKO (软骨特异性),pFNKO (肝细胞特异性) 和FNdKO (双淘汰赛).
  • 从产后第一天到成年期 (两个月) 的骨参数分析.
  • 微型CT扫描用于骨微型架构,生长板块组织学分析,以及对体和骨形成标记物的评估.

主要成果:

  • 在骨发育过程中观察到FN异型的明显的拓沉积模式.
  • 删除单个FN异型具有微妙的效果,但双重淘汰 (FNdKO) 显著减少了身体和骨的长度.
  • FNdKO小鼠表现出骨微架构受损,骨矿物质密度降低,骨髓脂肪增加,体发生变化和TGF-β1 / AKT信号失调.

结论:

  • 纤维素对体生成,软骨成熟和骨形成至关重要.
  • 无论cFN和pFN异型都在调节骨发育中发挥着关键的作用,尽管在区域上有所不同.
  • 通过FN介导的信号通路对于整体骨生长和平衡至关重要.