碳水化合物与蛋白质或脂肪比率与死亡率之间的关联:一项前性队列研究
Gyu-Hyeon Son1, Hye Sun Lee2, Yu-Jin Kwon3
1Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Clinical nutrition ESPEN
|August 19, 2024
概括
较高的碳水化合物与蛋白质和碳水化合物与脂肪的比率与增加全因死亡率有关. 减少过多的碳水化合物摄入可能有利于长寿和心血管健康.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 饮食中的宏观营养素平衡显著影响长寿和代谢健康.
- 了解宏观营养素比例与死亡率之间的关系对于公共卫生倡议至关重要.
研究的目的:
- 调查碳水化合物与蛋白质和碳水化合物与脂肪的比例以及全因和心血管死亡率之间的联系.
- 确定改善寿命和心血管健康的潜在饮食策略.
主要方法:
- 基于人口的研究,使用来自韩国基因组和流行病学研究和国家死亡记录的数据.
- 通过食物频率问卷评估饮食习惯,以确定宏观营养素的比例.
- 考克斯的比例危险回归模型和哈雷尔的C指数用于关联分析和切线确定.
主要成果:
- 碳水化合物与蛋白质的比率高 (>9.9) 与较高的全因死亡率 (HR 1.09) 有关.
- 较高的碳水化合物与脂肪比率 (>7.1) 与所有原因 (HR 1.08) 和心血管死亡率 (HR 1.27) 的增加有关.
- 碳水化合物与蛋白质的比例和心血管死亡率之间没有发现显著的关联.
结论:
- 研究结果表明,减少过多的碳水化合物摄入量和增加蛋白质和脂肪消费可能会促进寿命和心血管健康.
- 需要进一步的研究来阐明潜在的生物机制.
- 关注宏观营养素平衡的饮食建议可能在预防性健康策略中发挥作用.
相关概念视频
Overview of Carbohydrate Metabolism
820
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
820
Carbohydrates: Dietary Sources and Requirements
447
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
447
Odds Ratio
115
The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
115
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
124
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Hypothesis Test for Test of Independence
3.5K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
3.5K


