过早分娩与怀孕期间补充维生素D和之间的联系
Jiatao Zhang1, Shuoxin Bai2, Shaoqian Lin3
1Department of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, PR China.
Clinical nutrition ESPEN
|August 19, 2024
概括
怀孕期间同时补充维生素D和会增加早产风险,尤其是在一起服用时. 出生的体重部分介导了这种效应,关键窗口是妊娠3-6周.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 产前维生素D (VD) 和补充剂是常见的做法.
- 静脉疾病和对早产风险的综合影响尚不清楚.
研究的目的:
- 调查妊娠期间静脉疾病和联合补充剂之间的关联以及早产的发生率.
主要方法:
- 济南的一个出生队列基线调查.
- 通过关于早产和每月VD/补充剂的问卷收集的数据.
- 后勤回归和分布式滞后非线性模型被用于分析关联和关键窗口.
主要成果:
- 过早分娩发生在4.4%的单人活产中.
- 静脉疾病补充剂,特别是,与早产风险增加有关 (OR=1.600).
- 这种关联在怀孕的第3个月和第6个月之间是显著的,出生体重介导了10.8%的效果.
结论:
- 在怀孕期间同时服用静脉疾病和补充剂可能会增加早产风险.
- 出生的体重在这种关联中起着部分调解作用.
- 这种关联的关键时期似乎是在怀孕第3周到第6周之间.
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