在溶解过程中凝结后对共同形态新兴溶解行为进行研究:复合和抗结晶的重要性
Feiyan Pu1, Shiqi Wang1, Juanzi Yang1
1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China; Research Center for Pharmaceutical Preparations, Hubei University of Chinese Medicine, Wuhan 430065, PR China.
International journal of pharmaceutics
|August 19, 2024
概括
尽管凝,但taxifolin和oxymatrine的共同形态系统可以提高药物的溶解性. 复合和抗结晶性质改善溶解和生物可用性,为难溶性药物提供一种策略.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 共同形态 (CM) 系统可以提高难以溶解药物的可溶性.
- 溶解期间的凝可以阻碍CM的性能.
- 开发克服凝的策略对于CM疗效至关重要.
研究的目的:
- 为了创建taxifolin-oxymatrine共同形态系统 (TAX-OMT CMs).
- 为了提高taxifolin (TAX) 的溶解性和溶解性.
- 为了研究TAX-OMT CMs化后的溶解机制.
主要方法:
- TAX-OMT CMs 的构建和描述.
- 阶段溶解度,光谱学和异热定位热量计用于复杂化分析.
- 粉末X射线衍射,FTIR,SEM和分子模拟用于结构和相互作用研究.
- 在生体内对大鼠进行的药理动力学研究.
主要成果:
- 尽管凝,TAX-OMT CMs在TAX的溶解性和溶解性方面表现出显著的改善.
- 证实了TAX和OMT之间的复杂性.
- 其余的固体显示出抗结晶的特性.
- 在TAX-OMT CM (1:2) 中,TAX的口服生物利用率是晶体TAX的5.5倍.
结论:
- 在CM系统中,复杂化和抗结晶效应是维持化后溶解的关键.
- TAX-OMT CM 提供了一种有效的策略,用于改善难以溶解药物的吸收.
- 这项研究强调了一种新的方法,以克服制药共形系统中的凝挑战.
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