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低度二甲基硫氧化物 (DMSO) 调节了4-aminopyridine在体外模型中的型同步

Fei Ran Li¹, Mia Gemayel², Maxime Lévesque³

¹Montreal Neurological Institute-Hospital and Departments of Neurology & Neurosurgery and McGill University, 3801 University Street, Montréal, Québec H3A 2B4, Canada; Department of Physiology, McGill University, 3801 University Street, Montréal, Québec H3A 2B4, Canada.

Journal of neuroscience methods

|August 19, 2024

概括

常见的溶剂二甲基硫氧化物 (DMSO) 可以影响大脑活动. 即使在低度下,DMSO也会改变小鼠大脑切片中的类似发作的活动,这突显了它在神经学研究中的潜在混效应.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

甲基二硫氧化物 (DMSO) 是药理学研究中广泛使用的水不溶性药物的溶剂.
以前的研究表明,DMSO可能会影响神经元刺激性和活动.
即使在低度下,其潜在的混效应也需要仔细考虑.

研究的目的:

为了研究低度DMSO对型同步的影响.
为了评估DMSO在4 - 氨基胺 (4AP) 模型中的影响,在雄性小鼠大脑切片中.

主要方法:

在雄性小鼠大脑切片中利用了4-氨基胺 (4AP) 模型.
使用低度的DMSO (0.03%和0.06%).
测量了ictal排放速度和持续时间.

主要成果:

无论是0.03%还是0.06%的DMSO都增加了4AP诱导的液体排放的速度.
0.06%的DMSO显著减少了ictal排放的持续时间.
这些效应在比通常使用的度低得多的度下观察到.

结论:

低度的DMSO可以调节神经元刺激性和型同步.
研究人员必须意识到DMSO可能会混神经学和药理学研究的结果.
对DMSO对神经元活动的精确作用机制进行进一步的研究是有必要的.

关键词:

4 - 氨基胺-4-氨基胺-4-氨基胺-4-氨基胺甲基二甲基硫氧化物二甲基硫氧化物脑内内皮层 (entorhinal cortex) 是一个内脑皮层.伊克塔尔排放的排放情况

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