与代谢功能障碍相关的脂肪性肝病的流行病学
Zobair M Younossi1,2,3, Markos Kalligeros4, Linda Henry1,2,3
1The Global NASH Council, Washington DC, USA.
Clinical and molecular hepatology
|August 19, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响了38%的成年人,预计会增加. 这种情况显著影响肝脏健康,心血管结果和整体生活质量,需要采取全球行动.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 全球肥胖和2型糖尿病 (T2D) 率正在上升,导致代谢功能障碍相关的脂肪性肝病 (MASLD) 的增加.
- MASLD影响38%的成人和7-14%的儿童,预计到2040年,成年人患病率将超过55%.
- MASLD是美国妇女和HCC患者肝移植的主要原因,也是心血管疾病的主要风险因素.
研究的目的:
- 审查MASLD的流行病学,风险因素和结果.
- 为了突出MASLD带来的日益严重的公共卫生挑战.
- 强调需要采取全球倡议来打击MASLD日益增长的发病率.
主要方法:
- 对MASLD患病率的流行病学数据的文献综述.
- 对相关风险因素和并发症的分析.
- 检查临床结果,包括肝脏特异性和肝外并发症.
主要成果:
- MASLD的患病率很大,在成人和儿童中在全球范围内不断增加.
- MASLD与严重的肝脏结果 (肝硬化,HCC),心血管疾病,T2D,CKD和癌症有关.
- 与降低生活质量,生产力和增加医疗保健成本有关.
结论:
- MASLD代表着一个显著且日益增长的全球健康负担.
- 有效的生活方式干预对于MASLD管理至关重要.
- 如果没有全球举措,预计MASLD的发病率将继续上升,这凸显了针对性治疗和预防策略的必要性.
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