Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PMHS Sled Testing of Reclined Small Female Occupants: Pelvic Dynamics and Injury Evaluation.

Stapp car crash journal·2026
Same author

Treatment of Dupuytren Contracture Recurrence After Surgery With Collagenase Clostridium Histolyticum: A Retrospective Multicenter Series.

Journal of hand surgery global online·2026
Same author

Experimental wound ballistic study to understand biomechanical differences in gunshot wounds from various bullets and firearms: implications for clinical care and forensic analysis.

Forensic science, medicine, and pathology·2025
Same author

Methods for assessing submarining occurrence in PMHS frontal sled tests: Exploring potential indicators.

Traffic injury prevention·2025
Same author

Anisotropic mechanical properties of pediatric osteogenesis imperfecta bone in three-point bending between disease phenotypes and controls.

Journal of biomechanics·2025
Same author

Impactor Displacement as a Predictor of Thoraco-Abdominal Organ Injury: Comparison of Isolated Organ to Whole Body Tests.

Annals of biomedical engineering·2025

相关实验视频

Updated: Jun 23, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.5K

在体外皮肤穿孔方法用于材料表征.

Joseph LeSueur1, Carolyn Hampton2, Michael Kleinberger2

  • 1Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, WI, USA; Neroscience Research Labs, Zablocki Veterans Affairs Medical Center, WI, USA.

Medical engineering & physics
|August 19, 2024
PubMed
概括

了解自然皮肤张力对于准确的刺穿研究至关重要. 在生理张力下预先调节皮肤样本,提高了化品,手术和防护装备开发的机械测试可靠性.

关键词:
边界条件 边界条件 边界条件失败门的失败门.材料测试 材料测试 材料测试自然的紧张,自然的紧张.猪皮的皮肤是猪皮的预先调节的前提条件

更多相关视频

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

12.4K
Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

9.8K

相关实验视频

Last Updated: Jun 23, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.5K
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

12.4K
Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis
06:18

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

9.8K

科学领域:

  • 生物力学 生物力学
  • 材料科学 材料科学 材料科学
  • 皮肤病学 皮肤病学

背景情况:

  • 量化皮肤的机械特性对于化品,手术,法医和防护服至关重要.
  • 之前的皮肤刺穿研究缺乏一致的生理边界条件.
  • 皮肤表现出根据解剖位置的不同自然张力.

研究的目的:

  • 通过收缩实验来建立自然的皮肤张力.
  • 为了研究初始紧张和预先调节对皮肤穿孔抵抗力的影响.
  • 定义体外皮肤机械测试的最佳边界条件.

主要方法:

  • 来自不同解剖位置的猪皮肤样本被切除,以通过减小直径来测量自然张力.
  • 准静态刺穿试验是使用5毫米球形冲击器在不同初始张力和预调周期下对皮肤样本进行的.
  • 一个电液压负载框架和定制紧装置被用于受控测试.

主要成果:

  • 皮肤收缩因解剖位置而有显著差异 (腿:19.5%,侧翼:28.5%,腹部:38.4%).
  • 较低的初始张力 (<5%) 与较高的初始张力 (>25%,195.1N) 相比,导致故障时的力更高 (279.2N).
  • 八个预调节周期将hysteresis降低了45%,并显著减少了机械性质的变化.
  • 在生理张力 (14-25%) 的预条件样本显示,在故障时的正常化力 (278.3 N/mm) 比非条件样本 (234.4 N/mm) 更大.

结论:

  • 物理初始紧张和预先调节对于可靠的体外皮肤刺穿研究至关重要.
  • 解剖位置决定了皮肤的自然张力,必须复制才能进行准确的测试.
  • 在定义的边界条件下描述皮肤的机械行为有助于开发用于防护服和法医分析的有限元模型.