肥胖和大脑体积:通过心脏代谢和炎症指标的调解
Qi Zhou1,2, Wanlin Zhu1,2, Xueli Cai3,4
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Stroke and vascular neurology
|August 19, 2024
概括
通过BMI和WHR测量的肥胖会使大脑衰老加速大约4年. 心脏代谢和炎症因素部分介导这种对大脑体积的影响,特别是灰质和白质的超强度.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 肥胖,包括整体 (BMI) 和中央 (WHR) 措施,是一个日益严重的公共卫生问题.
- 肥胖对大脑健康的影响,特别是大脑体积,仍然是积极调查的领域.
- 了解心脏代谢和炎症因素的调解作用对于阐明肥胖的神经生物学后果至关重要.
研究的目的:
- 研究整体肥胖 (BMI) 和中心肥胖 (WHR) 与大脑体积之间的关联.
- 确定心脏代谢和炎症措施在多大程度上调解肥胖指数和大脑体积之间的关系.
主要方法:
- 使用反事实框架和调解分析.
- 检查了2413名社区居民参与者的数据.
- 评估了BMI,WHR,大脑体积 (GMV,WMHV) 和各种心脏代谢/炎症标志物之间的关系.
主要成果:
- 高BMI或WHR与大约4年的加速大脑衰老有关.
- 65岁以下的高BMI/WHR的个体显示了5年左右的加快白质超强度体积 (WMHV) 衰老.
- 超过45%的WHR对灰质体积 (GMV) 的影响是由葡萄糖代谢介导的;这增加到78.70%的额外因素.
- 心脏代谢和炎症指标介于对WMHV的影响的35.50% (WHR) 和20.20% (BMI).
结论:
- 总体和中心肥胖与灰质体积 (GMV) 减少和白质超强度体积 (WMHV) 增加有关.
- 这些与肥胖有关的脑部变化部分是由心脏代谢和炎症因素介导的.
- 这些发现凸显了肥胖对大脑结构和相关途径的有害影响.
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