以患者为中心的长效注射和植入平台――一个工业前景
Simone Alidori1, Raju Subramanian2, René Holm3
1Independent Researcher, Havertown, Pennsylvania 19083, United States.
Molecular pharmaceutics
|August 19, 2024
概括
长效注射剂 (LAI) 提高了患者的方便性和治疗遵守性. 本分析回顾了LAI技术,突出了配方见解和预测性体外溶解方法的关键需求.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 以患者为中心的护理
背景情况:
- 越来越强调以患者为中心和不断变化的医疗保健需求.
- 长效注射剂 (LAI) 提供降低剂量频率,改善患者的方便性和遵守性.
- 患者群体,包括艾滋病毒和精神分裂症患者,希望更少的治疗频率.
研究的目的:
- 在各种治疗类别和技术中对市场上销售的长效注射剂 (LAI) 进行全面分析.
- 提供与不同LAI配方技术相关的物理化学特性和辅助剂的见解.
- 讨论 LAI 的配方原理,制造和预测性体外释放方法的开发.
主要方法:
- 对市场上销售的LAI产品进行了全面分析.
- 对配方技术的审查,包括水性悬浮液,溶液,聚合物微球和in situ形成凝.
- 讨论物理化学性质,辅助剂,释放机制和制造方法.
主要成果:
- 越来越多的LAI进入市场,最近的趋势有利于水性悬浮液和溶液.
- 识别各种应用技术平台,如聚合物微球和in situ形成凝.
- 了解不同LAI技术的物理化学特性和典型辅助剂.
结论:
- 随着LAI技术的进步,它为患者带来了好处,并提供了多种配方选择.
- 对于LAI创新的系统制定和制造调查仍然存在重大差距.
- 使用药典设备开发预测性体外溶解方法对于LAI产品开发和质量控制至关重要.
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