Stat1/Nrf2通路在加剧crizotinib诱导的肝损伤中的参与:对铁亡的含义

Lin Guo1,2,3, JiaTing Ma1,2,3, MingXuan Xiao1,2,3

  • 1Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, China.

Cell death & disease
|August 19, 2024
PubMed
概括

克里佐提尼布可以通过细胞死亡途径铁死 (ferroptosis) 引起肝损伤. 研究人员发现,抑制铁亡和向Stat1/Nrf2通路可能会防止Crizotinib诱导的肝毒性.

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