系统性免疫炎症指数和心血管--代谢综合征之间的关联
Chenxuan Gao1, Shizhen Gao1, Renpei Zhao1
1Department of Cardiology, The Second People's Hospital of Baoshan, No.13, Zhengyang (S) Rd., Longyang Dist., Baoshan, Yunnan, China.
系统性免疫-炎症指数 (SII) 与心血管--代谢 (CKM) 综合征及其组成部分的更高风险有关. 升高的SII水平显示了剂量反应关系和非线性影响与CKM综合征的发展.
科学领域:
- 心血管研究的心血管研究.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢综合征研究研究
背景情况:
- 心血管-脏-代谢 (CKM) 综合征是一种复杂的疾病,涉及心血管疾病,脏疾病和代谢功能障碍.
- 系统性免疫炎症指数 (SII) 源自常规血液计数,正在成为系统性炎症的潜在标志物.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与心血管--代谢 (CKM) 综合征的患病率之间的关联.
- 探索SII和CKM综合征的单个组成部分之间的关系,包括心脏代谢综合征 (CMS) 和慢性病 (CKD).
主要方法:
- 分析了2001-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用加权后勤回归模型来评估SII和CKM综合征之间的关联.
- 限制立方线和断片线性回归被用来识别非线性关系和值效应.
主要成果:
- 较高的SII水平始终与CKM综合征及其组成部分的可能性增加有关.
- 在SII的1000个单位的增加与CKM综合征的1.48倍增加的几率相关 (95% CI 1.20-1.81).
- 对于几个CKM成分,观察到剂量反应和非线性关系,确定了值效应.
结论:
- 系统性免疫-炎症指数 (SII) 是心血管--代谢 (CKM) 综合征风险的显著正相关值.
- 有证据表明,SII和特定的CKM组件之间存在非线性关联和值效应,突出其临床相关性.
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