相关实验视频

Updated: Jun 16, 2025

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide

Published on: December 15, 2014

一种以乳酸细菌为基础的吸入活体生物治疗产品减轻了肺中性友好性炎症

Teodora Nicola¹, Nancy Wenger¹, Xin Xu^2,3

¹Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.

Nature communications

|August 19, 2024

概括

使用Lactobacillus的新型吸入活生物疗法 (LBP) 通过向MMP-9/PGP通路,改善肺功能和结构,有效治疗支气管肺功能障碍 (BPD) 和慢性阻塞性肺病 (COPD).

科学领域:

肺部医学肺部医学
微生物学微生物学
炎症研究炎症研究

背景情况:

支气管肺功能障碍症 (BPD) 是早产婴儿的慢性肺部疾病,与成人慢性阻塞性肺部疾病 (COPD) 相关,原因是肺部退化和中性粒细胞流入等共同特征.
无论是BPD还是COPD都表现出肺部微生物群的改变,特别是固体管的枯竭,但细菌在疾病进展中的作用尚不清楚.
乙化氨酸-甘氨酸-氨酸 (Ac-PGP) 途径和中性粒细胞活性与BPD的发展有关.

研究的目的:

研究Ac-PGP途径在BPD发展中的作用.
评估一种含有乳杆菌菌株的吸入活生物疗法 (LBP) 用于治疗BPD和COPD模型.
阐明慢性肺部疾病中LBPs的治疗机制.

主要方法:

利用小鼠模型研究BPD的发展和Ac-PGP的影响.
进行了功能增益和丧失研究,以确定Ac-PGP在BPD中的作用.
在体外和体内测试了基于乳酸菌的吸入LBP的BP和COPD模型.

主要成果:

发现Ac-PGP在推动BPD发展方面发挥着关键作用.
基于乳杆菌的LBP在BPD和COPD模型中显著改善了肺部结构和功能.
通过MMP-9/PGP通路,LBP治疗减轻了中性粒细胞的流入,并减少了促炎性标志物.

结论:

吸入的LBP在慢性肺部疾病 (如BPD和COPD) 中具有治疗潜力.
用乳杆菌向MMP-9/PGP通路提供了一个有希望的策略来控制肺炎和退化.
LBPs可能会解决适用于各种慢性肺部疾病的常见疾病进展机制.

更多相关视频

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Published on: March 2, 2016

相关概念视频

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Drugs Used in Lower Respiratory Disorders: Overview

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...