白质脑年龄在各种形式的和间接性精神病中
Daichi Sone1,2, Iman Beheshti3, Yoko Shigemoto4
1Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan. daichisone@gmail.com.
Scientific reports
|August 19, 2024
概括
会加快大脑的衰老,特别是在白质区域,这是大脑预测年龄差异 (大脑-PAD) 的增加所表明的. 并发性精神病进一步加剧了叶 (TLE) 中这种加速的大脑衰老.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 与大脑网络功能障碍有关.
- 白质道对大脑连接至关重要,在中可能会受到影响.
- 在患者中,大脑衰老过程可能会发生变化.
研究的目的:
- 为了研究不同类型的白质大脑衰老.
- 为了检查并发性精神病对中大脑衰老的影响.
- 评估大脑预测年龄差异 (大脑-PAD) 作为加速衰老的标志物.
主要方法:
- 在3T-MRI中从257名患者和429名健康对照中获得的扩散张力成像 (DTI) 数据.
- 一个大脑年龄预测模型,使用健康受试者的通道基分数异性质值来构建.
- 为所有参与者计算大脑-PAD (预测年龄 - 计时年龄).
主要成果:
- 大多数类型的患者表现出大脑PAD显著增加,这表明大脑衰老加速.
- 带有海马硬化症的叶 (TLE) 显示出大幅增加 (+9.1年).
- 在TLE患者中,间接性精神病显著增加了8.7年的脑PAD.
结论:
- 加速白质大脑衰老在大多数类型中普遍存在.
- 精神病可能是TLE中加速大脑衰老的促成因素.
- 这些发现表明和相关的精神病症状中存在异常的衰老机制.
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