在肥胖的哺乳期妇女中,与正常体重相比,母乳占主导地位的细菌和益生菌
Shahla Karami1, Seyedeh Neda Mousavi2, Reza Shapouri3
1Department of Microbiology, Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
Scientific reports
|August 19, 2024
概括
孕产妇的肥胖会影响母乳中的细菌. 肥胖的母亲具有较低的有益的Bifidobacterium spp.水平. 和其他关键细菌,可能会影响婴儿的生长.
科学领域:
- 微生物学 微生物学
- 人类营养人类营养
- 公共卫生 公共卫生
背景情况:
- 孕产妇肥胖是一个日益严重的全球健康问题.
- 母乳微生物群在婴儿的发育和健康中起着至关重要的作用.
- 了解母亲体重对母乳成分的影响至关重要.
研究的目的:
- 为了比较肥胖母亲与正常体重母亲的母乳中占主导地位的细菌类 (Bacteroidetes, Firmicutes, Actinobacteria) 和特定属 (Bifidobacterium spp., Lactobacillus) 的丰度.
- 调查母亲怀孕前和当前体重,分娩方式以及母乳细菌组成之间的关联.
- 探索母乳细菌丰富度和婴儿生长参数 (身高) 之间的关系.
主要方法:
- 招募了60名健康的伊朗妇女在哺乳期第四个月的队列.
- 参与者被分为肥胖 (BMI ≥30 kg/m2) 和正常体重 (18.5 ≤BMI ≤24.9 kg/m2) 的组.
- 从捐赠的母乳中提取细菌DNA,并进行针对16S rRNA基因的qPCR. 使用多个线性混合模型进行统计分析.
主要成果:
- 这种细菌是Bifidobacterium spp. 与肥胖母亲相比,正常体重的母亲的丰度明显高.
- 母亲当前体重显著影响了Actinobacteria的丰富性.
- 在经过剖腹产的母亲中,细菌体和固体体的水平较低.
- 怀孕前的肥胖与Firmicutes和Lactobacillus的水平降低有关.
- 动氨菌和双菌 spp. 的作用. 丰富度与婴儿身高正相关.
结论:
- 当前和怀孕前的母亲体重状况显著影响母乳微生物群的组成,特别是像Bifidobacterium spp.这样的有益细菌.
- 剖腹产与较低水平的细菌菌体和细菌菌体有关.
- 特定的母乳细菌的丰富性,如Actinobacteria和Bifidobacterium spp.,可能与婴儿的生长,特别是身高有关.
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