多喷嘴雾化器在PIPAC期间不会改善组织药物输送
Yaroslaw Sautkin1,2, Juergen Weinreich3,4, Marc André Reymond3,4
1National Center for Pleura and Peritoneum, University Hospital Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. Yaroslav_sautkin@gmx.de.
Surgical endoscopy
|August 19, 2024
概括
与单喷嘴设备相比,用于腹腔内气溶化疗 (PIPAC) 的多喷嘴雾化器没有改善药物输送. 在ex vivo模型中,Capnopen®显示出优越的组织药物度和对cisplatin输送的同质性.
科学领域:
- 在瘤学瘤学.
- 药物输送系统 药物输送系统
- 医疗器械 医疗器械
背景情况:
- 压缩性腹腔内喷雾剂化疗 (PIPAC) 使用多喷嘴雾化器来增强均的组织药物输送.
- 之前的研究没有明确证明多喷嘴比单喷嘴PIPAC设备的优越性.
- 这项研究旨在比较PIPAC应用中的多喷嘴和单喷嘴雾化器的性能.
研究的目的:
- 为了比较多喷嘴和单喷嘴 (Capnopen®) PIPAC雾化器的物理和药理性能.
- 评估气溶特性,组织药物输送和药物分配均性.
- 为了确定多喷嘴设备是否比Capnopen®在体外模型中具有优势.
主要方法:
- 物理实验:气溶液滴大小分析 (激光衍射光谱) 和在抹纸上可视化空间喷雾模式.
- 药理学实验:用于实时组织药物输送评估的ex vivo牛尿膀模型.
- 对这两种雾化剂类型的多克索鲁比辛和西斯普拉丁组织分布和度的评估.
主要成果:
- 多喷嘴雾化器表现出更大的气溶流量和更宽的喷雾角度,但颗粒大小更大.
- 组织药物递送率相似;气溶沉积没有显示设备之间的显著差异.
- 卡普诺®实现了更高的多克索鲁比辛和西斯胺组织度,与显著更好的西斯胺分布均性.
结论:
- 多喷嘴PIPAC雾化器在体外药物输送和均性方面没有超过单喷嘴Capnopen®.
- 尽管喷雾模式更广泛,但多喷嘴装置导致组织药物度较低.
- 卡普诺®在组织药物度和同质性方面表现出卓越的表现,特别是对于西斯.
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