网红酸诱导的蛋白14将机械力量与河马信号联系起来
Wonyoung Jeong1, Hyeryun Kwon1, Sang Ki Park2
1Department of Life Science, University of Seoul, Seoul, 02504, Republic of Korea.
EMBO reports
|August 19, 2024
概括
网红酸诱导蛋白14 (RAI14) 通过调节YES相关蛋白 (YAP) 活性,将机械力量与Hippo信号通路联系起来. 这一发现揭示了机械传导和癌症进展.
科学领域:
- 细胞生物学 细胞生物学
- 机械生物学 机械生物学
- 癌症生物学 癌症生物学
背景情况:
- 细胞通过actin细胞骨架从细胞外基质感知机械力.
- 机械传导将机械刺激转化为生物化学信号.
- 是-关联蛋白 (YAP) 是机械传导和Hippo信号的关键媒介,但其通过机械力量的调节仍然不清楚.
研究的目的:
- 调查视网酸诱导蛋白14 (RAI14) 在感知机械力和调节河马信号传递中的作用.
- 阐明RAI14影响YAP活动和Hippo通路组件的机制.
主要方法:
- 研究了RAI14与NF2以及在不同力下有丝状动蛋白的相互作用.
- 评估了RAI14对YAP活动和Hippo通路信号传导 (LATS1相互作用) 的影响.
- 分析了与组织度,RAI14/YAP表达和胃癌患者结局相关的临床数据.
主要成果:
- RAI14积极调节YAP活动.
- RAI14与NF2在丝状活性蛋白上相互作用.
- 较低的机械力导致NF2与RAI14和actin分离,促进LATS1相互作用和Hippo通路激活.
- 瘤组织中RAI14和YAP的表达率升高,并与胃癌的不良预后有关.
结论:
- RAI14充当了机械传导和Hippo信号之间的关键联系.
- RAI14调解与Hippo通路相关的功能,包括癌症进展.
- RAI14代表了与改变机械传导相关的癌症的潜在治疗标.
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