干乐素-6与心血管疾病预测算法和风湿性关节炎患者的生物标志物具有积极的相关性
Seyed Askar Roghani1,2,3, Afsaneh Shamsi1, Cyrus Jalili3
1Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Journal of cellular and molecular medicine
|August 19, 2024
概括
在类风湿性关节炎 (RA) 患者中,高水平的干白素-6 (IL-6) 与心血管疾病 (CVD) 风险因素和生物标志物相关. IL-6可以作为预测RA未来心血管事件的关键指标.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性炎症与类风湿性关节炎 (RA) 和心血管疾病 (CVD) 有关.
- 干白素-6 (IL-6),一种促炎性细胞因子,在RA的发病过程中至关重要,并与关节的破坏有关.
- 在RA患者中IL-6对心血管疾病风险的作用需要进一步研究.
研究的目的:
- 为了评估血中介质素-6 (IL-6) 水平和RA患者心血管风险标志物之间的关联.
- 为了将RA患者的IL-6水平与健康对照进行比较.
- 探索IL-6,心脏生物标志物 (NT-proBNP,HS-CRP),心血管疾病风险得分 (FRS,SCORE) 和免疫标志物 (CXCL9,CXCR3) 之间的关系.
主要方法:
- 横截面研究包括60名RA患者 (30名早期,30名晚期) 和30名健康对照.
- 使用ELISA对血IL-6和NT-proBNP进行量化.
- 通过免疫度测定测量HS-CRP.
- 使用弗雷明汉风险评分 (FRS) 和系统冠状动脉风险评估 (SCORE) 评估心血管疾病风险.
主要成果:
- 关节炎患者的IL-6血水平明显高于对照组 (p < 0.001).
- IL-6与RA疾病活性评分 (DAS-28,BPS,BPD),心血管疾病风险评分 (SCORE,FRS),HS-CRP,NT-proBNP,CXCL9和CXCR3正相关.
- 在RA患者中,IL-6与HDL水平呈负相关性.
结论:
- 在RA患者中,IL-6显著升高,并且与多种心血管风险因素和生物标志物密切相关.
- 这些发现表明IL-6可能是评估RA患者未来心血管事件风险的有价值生物标志物.
- 向IL-6可能提供一种治疗策略,以减轻RA中的心血管疾病风险.
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