黄素对微塑料和纳米塑料毒性的保护作用
Habibeh Mashayekhi-Sardoo1,2, Samaneh Sepahi3, Adel Ghorani-Azam4
1Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran.
International journal of environmental health research
|August 20, 2024
概括
微塑料和纳米塑料 (MNP) 导致广泛的器官毒性. 黄素是一种天然化合物,在临床前研究中通过利用其抗氧化和抗炎性质,有效地保护其免受这些有害影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- 微塑料和纳米塑料 (MNP) 是城市尘埃和水生生态系统中发现的新兴环境污染物.
- 人体组织中MNP的积累,包括胃肠道和肺部,导致缓慢发展的毒性.
- 黄素已被确定为一种潜在的天然剂,可以减轻环境毒素引起的破坏.
研究的目的:
- 审查研究黄素对微塑料和纳米塑料 (MNP) 毒性的保护作用的临床前研究.
- 要总结MNP暴露引起的毒性范围.
- 评估黄素在逆转MNP诱导的细胞和器官损伤方面的疗效.
主要方法:
- 对黄素和MNP毒性的临床前研究进行系统审查.
- 分析详细介绍MNP诱导的器官损伤和细胞病理的研究.
- 评估黄素的生化和本病学保护机制.
主要成果:
- 暴露于MNP与各种毒性有关,包括骨解,免疫毒性,甲状腺,脏,大脑,肝脏,肺部,胃肠道,心血管,内分泌和生殖系统.
- 在大多数审查的研究中,黄素显示出显著的保护作用,恢复了MNP引起的氧化和组织病理损伤.
- 黄素的益处归因于其抗氧化,抗,抗炎和抗增殖性质.
结论:
- 黄素作为天然治疗剂对抗微塑料和纳米塑料 (MNP) 的有毒作用,显示出相当大的前景.
- 需要进一步的研究来探索黄素在管理MNP相关的健康风险中的临床应用.
- 这些发现凸显了天然化合物在打击环境污染引起的疾病方面的潜力.
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