与中国老年男性人口的死亡率相关的禁食过高甘油血症
Xin-Yu Wang1, Xiao-Fei Ye1, Wen-Yuan-Yue Wang1
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of clinical hypertension (Greenwich, Conn.)
|August 20, 2024
概括
禁食高血糖血预测中国老年男性的死亡率,但只有在他们没有高血压的情况下. 这一发现强调了管理甘油三水平的重要性,特别是在正常压力的人群中.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 禁食高甘油三血是老年人群中常见的代谢状况.
- 它与死亡风险的关联,特别是在特定的种族群体和与其他心血管风险因素结合,需要进一步调查.
- 了解这些关联对于有针对性的公共卫生干预至关重要.
研究的目的:
- 调查禁食高甘油三血症是中国老年男性所有原因,心血管和非心血管死亡率的预测因素.
- 检查过高甘油三血症和常规心血管风险因素之间的相互作用,包括高血压,吸烟,饮酒和高血糖.
- 为了确定是否高血甘油三血症在正常血压与高血压个体中构成差异性死亡风险.
主要方法:
- 一项涉及1583名居住在上海的中国老年男性 (≥60岁) 的队列研究.
- 测量了禁食血清甘油三甲酸,高甘油三甲酸血症的定义为≥1.70 mmol/L.
- 死亡结果 (所有原因,心血管,非心血管) 被追踪了7.9年的中位数,根据高血压,吸烟,酒精摄入量和高血糖进行了亚组分析.
主要成果:
- 在调整混因素后,禁食高甘油三血症与所有原因,心血管或非心血管死亡率没有显著关联.
- 观察到过高甘油三血症和高血压之间的显著相互作用,涉及所有原因的死亡率 (p=0.03).
- 在正常血压的个体中,高甘油三血症与所有原因 (HR 1.57) 和心血管死亡风险的增加显著相关,这种发现在高血压个体中没有观察到.
结论:
- 禁食高甘油三血是中国老年男性全因和心血管死亡的重要预测因素,但只有在没有高血压的情况下.
- 研究结果表明,对正常血压的老年男性来说,控制甘油三可能特别有益.
- 这些结果强调了代谢因素和并发症之间的复杂相互作用,决定了老龄化人口的死亡风险.
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