婴儿结肠与晚期便秘和亚托皮性疾病的发展有关
Jakob Stokholm1,2,3, Jonathan Thorsen1, Ann-Marie Malby Schoos1,3
1Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Allergy
|August 20, 2024
概括
婴儿大肠与患上便秘和在幼儿时期患喘和湿疹等类型疾病的风险更高有关. 这些风险并不能用婴儿1个月大时肠道微生物组的差异来解释.
科学领域:
- 儿科健康 儿科健康
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 婴儿结肠是一种常见的疾病,其长期健康影响尚不清楚.
- 对于早期生活肠道微生物组与以后的亚托皮性或胃肠道疾病之间的联系的理解有限.
研究的目的:
- 为了研究早期生活肠道微生物组在婴儿大肠中的作用.
- 评估婴儿结肠和随后的阿托皮和胃肠道疾病的发展之间的联系,直到6岁.
主要方法:
- 利用哥本哈根前性儿童喘研究 (2010) 队列,在6年内跟踪695名儿童.
- 通过16S rRNA测序分析了1个月的肠道微生物组,并在三个月后通过采访评估了婴儿结肠.
- 评估的临床终点包括便秘,喘,亚托皮炎和过敏敏感性到6岁.
主要成果:
- 婴儿结肠发作发生在7.9%的儿童中;虽然与特定的微生物组合没有直接联系,但九种物种的模型中度预测了结肠发作 (AUC=0.627).
- 患有婴儿的儿童出现后来的便秘风险增加 (aOR=2.88),喘 (aHR=1.69),亚托皮炎 (aHR=1.84),以及更多的过敏成分.
- 这些关联并非由一个月大时的肠道微生物群差异介导.
结论:
- 婴儿结肠与在生命的前六年内患上便秘和亚托皮性疾病的风险增加有关.
- 观察到的风险并不能通过1个月大时肠道微生物组的改变来解释.
- 这些发现表明,婴儿结肠可能涉及潜在的胃肠道和/或亚托皮机制,独立于早期微生物组合.
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