使用化疗-免疫疗法治疗晚期胆囊癌的进化方法,具有完整的病理反应:一个病例报告
Elena Orlandi1, Ilaria Toscani1, Serena Trubini1
1Department of Oncology-Hematology, Piacenza General Hospital, I-29121 Piacenza, Italy.
Oncology letters
|August 20, 2024
概括
化疗免疫疗法对转移性胆管癌 (CCA) 和胆囊癌 (GBC) 是有前途的,导致一些患者显著减少瘤和完全反应. 需要进一步的研究来确定预测治疗成功的生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠道癌症 胃肠道癌症
背景情况:
- 转移性胆管癌 (CCA) 和胆囊癌 (GBC) 的治疗选择有限.
- 化学疗法与免疫疗法相结合显示出改善的生存率和反应率.
- 之前的试验,如TOPAZ-1和KEYNOTE-966,已经确定了化学免疫治疗在GBC中的疗效.
研究的目的:
- 评估化学免疫治疗在患有晚期,不可切割的GBC的患者的疗效.
- 评估完整反应的可能性和新辅助治疗后手术的作用.
- 探索分子分析对治疗反应的影响.
主要方法:
- 一名无法切除的GBC患者接受了西斯普拉丁-凝丁加杜尔瓦卢马布.
- 治疗包括八个周期的化疗免疫疗法,然后是维护性杜尔瓦卢马布.
- 通过成像和瘤标志物监测瘤反应,导致手术切除.
主要成果:
- 患者实现了显著的瘤体积减少和瘤标记物的正常化.
- 手术后的组织学检查证实,没有剩余的瘤和淋巴结转移.
- 患者在治疗后一年多的时间里一直没有患病.
结论:
- 化疗免疫疗法可以诱导晚期GBC的完整反应,从而有可能实现治愈性手术.
- 新辅助免疫治疗后手术的作用需要进一步研究.
- 识别PD-L1表达之外的预测生物标志物对于优化治疗策略至关重要.
相关概念视频
01:27Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K