在1型早产视网膜病变中注射贝瓦西祖马布后的二次玻璃眼
Anthony A Jones1,2, Jacob S Martin1,2, Annette L Giangiacomo1,2
1Department of Ophthalmology, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, USA.
American journal of ophthalmology case reports
|August 20, 2024
概括
在早产婴儿中,对早产儿视网膜病变 (ROP) 进行静脉内贝瓦西祖马布 (抗VEGF) 治疗可能导致二次玻璃眼. 这项研究调查了抗VEGF疗法与非常早产婴儿的玻璃眼瘤发展之间的潜在联系.
科学领域:
- 眼科医生 眼科 眼科
- 新生儿科学 新生儿科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 早产儿视网膜病变 (ROP) 是早产儿的一个重大问题.
- 静脉内贝瓦西祖马布 (抗VEGF) 用于治疗严重的ROP.
- 在怀孕24周或之前出生的早产婴儿面临ROP的高风险.
研究的目的:
- 报告三例在1型ROP中经过室内贝瓦西祖马布治疗后出现的二次绿眼病.
- 为了调查抗VEGF治疗与极早产婴儿的玻璃眼之间潜在的关联.
- 探索一种可能的新途径,用于眼病的发展.
主要方法:
- 三个婴儿的案例系列出生 ≤24周怀孕.
- 在月经后34周 (PMA) 或之前使用内内贝瓦齐祖马布治疗1型ROP.
- 在治疗后监测前段变化和青光眼的发展.
主要成果:
- 这三名患者在注射抗VEGF药物后大约4周内都出现了疑似开角青光眼 (OAG).
- 治疗前的检查显示前腔结构正常,并且没有青光眼的迹象.
- 青光眼的呈现与以前报告的病例不同.
结论:
- 在极早早产的婴儿中,早期给药的静脉内抗VEGF药物可能会增加继发性玻璃眼的风险.
- 假设一种潜在的新途径将抗VEGF疗法与青光眼的发展联系起来.
- 需要进一步的研究来阐明机制并确认这种关联.
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