乳酸细菌菌株的多功能性质来源于狗便
Yunjiang Liu1, Jiali Wang1, Haohong Zheng1
1Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Frontiers in veterinary science
|August 20, 2024
概括
这项研究分离和表征了狗乳酸细菌 (LAB) 菌株,确定了11种狗健康补充剂具有显著的益生菌潜力. 这些LAB表现出抗微生物,粘附,抗氧化剂和代谢物产生能力.
科学领域:
- 微生物学 微生物学
- 动物科学动物科学
- 益生菌研究 益生菌研究
背景情况:
- 益生菌,特别是乳酸细菌 (LAB),通过调节肠道微生物群和免疫反应,为动物提供健康益处.
- 狗的肠道健康至关重要,识别有效的益生菌菌株是一个正在进行的研究领域.
研究的目的:
- 为了隔离和全面评估来自犬类的乳酸细菌 (LAB) 菌株的益生菌性质.
- 为了确定LAB菌株的潜在应用,作为狗食补充剂的功能成分.
主要方法:
- 从狗便样本中分离了206个LAB菌株.
- 根据生长,抗酸/胆盐耐药性以及抗病原性活性,粘附性,安全性,抗氧化能力和代谢物产生的评估,选择了11个候选菌株.
- 使用了致病原体抑制,细胞粘附 (Caco-2),抗生素敏感性,血液溶解,抗氧化活性 (DPPH,OH-,H2O2) 和代谢物分析 (EPS,GABA,BSH) 的分析.
主要成果:
- 十一种LAB菌株表现出强大的抑制和协聚作用,对抗关键的犬病原体 (大肠杆菌,金黄色,S. braenderup,P. aeruginosa).
- 选择的LAB菌株表现出优异的粘附性质,包括高水性,自聚,生物膜形成和Caco-2细胞粘附,其中L. acidophilus L177表现出显著的性能.
- 所有测试的LAB菌株对抗生素敏感,非溶血性,表现出良好的H2O2耐受性和强大的DPPH和基清除活动,同时产生显著水平的EPS,GABA和BSH.
结论:
- 来自狗的LAB菌株具有多种多功能益生菌特性,包括抗菌,粘合剂,抗氧化剂和有益的代谢物产生能力.
- 这些特征化的LAB菌株是开发成犬类食补充剂的有希望的候选人,以促进整体健康.
- 建议进行进一步的体内研究,以证实这些益生菌株在犬类动物中的有效性和实际应用.
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