肠道微生物群,免疫细胞和冠状动脉心脏病之间的因果关系:一种介导的孟德尔随机化分析
Feifei Yang1, Hui Song1, Weizhi Tang1
1Graduate School of Guangxi University of Chinese Medicine, Nanning, China.
Frontiers in microbiology
|August 20, 2024
概括
肠道细菌如Desulfovibrio piger可能通过改变T细胞种群来影响冠心病 (CHD) 风险. 调节肠道微生物群和免疫细胞可能有助于减少心脏病发病率.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 心血管疾病流行病学
背景情况:
- 肠道微生物群 (GM),免疫细胞和冠状动脉心脏病 (CHD) 相互关联.
- 转基因,免疫细胞和心脏病风险之间的因果关系在很大程度上仍未被探索.
研究的目的:
- 调查转基因,免疫细胞和心脏病风险之间的因果关系.
- 通过介导的门德尔随机化 (MR) 分析,揭示转基因和免疫细胞对患心脏病的风险的影响.
主要方法:
- 利用全基因组关联研究 (GWAS) 对转基因,免疫细胞和冠心病的数据.
- 进行了门德尔随机化 (MR) 分析,以评估转基因,免疫细胞和冠心病之间的因果关系.
- 采用了各种MR方法,包括逆方差加权 (IVW),MR-Egger回归和加权中位数.
主要成果:
- 确定了6种转基因和25种与心脏病相关的免疫细胞类型.
- 发现 *g__Desulfovibrio.s__Desulfovibrio_piger* 丰度与EM DN (CD4-CD8-) %T细胞具有积极的相关性.
- 观察到EM DN (CD4-CD8-) %T细胞与心脏病风险降低有关.
结论:
- 增加的 *g__Desulfovibrio.s__Desulfovibrio_piger* 丰度导致更高的EM DN (CD4-CD8-) %T细胞数量,这反过来又降低了心脏病风险.
- 表明调节转基因和免疫细胞可能是减少心脏病发病率的策略.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
Introduction to the Human Microbiota
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...


