南亚印度人和高加索男性的维生素D状况,骨和身体组成的种族差异
A Altasan1, A Aljahdali2,3, R Ramadoss4
1Department of Clinical Nutrition, King Saud University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Metabolism open
|August 20, 2024
概括
与白人相比,年轻的南亚印第安人 (SAI) 的维生素D状况,骨健康和身体成分较差. 骨和代谢健康的这些种族差异在生命的早期显而易见,这表明针对少数群体的有针对性的干预措施.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 少数民族,包括南亚印第安人 (SAI),与高加索人群相比,代谢异常和骨健康问题更高.
- 这些差异往往归因于身体组成和内分泌因素的差异,SAI增加了代谢综合征和骨健康不佳的风险.
- 以前的研究往往侧重于老年移民群体,需要对年轻人和最近的移民进行调查.
研究的目的:
- 调查年轻南亚印第安人 (SAI) 男人和高加索男性之间的维生素D状况,骨健康和身体组成的差异.
- 为了比较这些参数,特别是最近的SAI移民和高加索人群之间的参数.
主要方法:
- 一项比较性研究涉及60名健康的年轻男子 (30名SAI,30名高加索人),平均年龄为27.8岁.
- 血清25-基维生素D (s25(OH) D,副甲状腺激素 (sPTH),维生素D结合蛋白 (sDBP),骨质素 (sOC),骨矿物质密度和身体组成 (瘦质%,无脂肪质%,脂肪质%) 的评估.
- 在两组中评估饮食摄入量.
主要成果:
- 与高加索人相比,SAI显示s25(OH) D水平明显较低,sPTH水平较高 (p < 0.05).
- 仅在SAI组 (r = -0.389,p = 0.037) 中观察到s25(OH) D和sPTH之间的负相关性.
- 与白人相比,SAI表现出较低的肌肉质量%和无脂肪质量%,并且在大多数部位减少了骨矿物质密度 (p <0.05).
结论:
- 年轻的SAI呈现出低于最佳的维生素D状态,不太有利的骨健康,与他们的高加索同龄人相比,不同的身体组成参数.
- 这些发现强调了骨和代谢健康之间潜在的复杂相互作用,这种相互作用在不同种族的早期生活中表现出来.
- 旨在改善骨和代谢健康的干预措施应优先考虑年轻的少数民族人口.
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