患有细胞癌的患者的治疗偏好:离散选择实验的结果
Moshe C Ornstein1, Lisa C Rosenblatt2, Xin Yin2
1Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Patient preference and adherence
|August 20, 2024
概括
患有晚期/转移性细胞癌 (aRCC) 的患者在选择治疗时优先考虑生存时间和生活质量 (QoL). 治疗方案的方便性也很重要,而副作用和反应率则不那么重要.
科学领域:
- 在瘤学瘤学.
- 医学经济学 医学经济学
- 患者报告的结果
背景情况:
- 晚期/转移性细胞癌 (aRCC) 的治疗已经被第一线免疫疗法的出现所改变.
- 了解患者的偏好对于优化治疗选择在不断变化的ARCC环境中至关重要.
研究的目的:
- 调查患者对晚期/转移性细胞癌 (aRCC) 治疗特征的偏好.
- 确定患者在选择aRCC治疗时愿意做出的关键权衡.
主要方法:
- 在美国,对299名患有aRCC的成年患者进行了一项使用离散选择实验的在线横截面调查.
- 评估的治疗属性包括无进展生存率,生存时间,客观反应率,反应持续时间,严重副作用风险,生活质量 (QoL) 和治疗方案的便利性.
主要成果:
- 患者将生存时间的改善列为最关键的因素 (增加10%至55%).
- 改善生活质量 (QoL) 和方便的治疗方案 (例如,更少的输液) 是下一个最重要的属性.
- 严重不良事件的风险,无进展的生存率,客观反应率 (ORR) 和反应持续时间 (DOR) 被患者认为不那么重要.
结论:
- 对于aRCC患者来说,生存时间和生活质量 (QoL) 是最重要的考虑因素.
- 治疗决策的讨论应该包括更广泛的因素,包括QOL影响和治疗方案的方便性,以及传统的疗效措施.
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