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富含安托氨酸的蔓越提取物以独立于肠道菌群的方式减轻DSS诱导的IBD

Jun Wang¹, Zhong-Yu Yuan¹, Xin-Yu Wang¹

¹Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China.

Current research in food science

|August 20, 2024

概括

蔓越提取物富含抗生素,通过调节铁亡,在小鼠中减轻炎症性肠病 (IBD),而不是主要通过改变肠道微生物群. 这为IBD管理提供了一种新的治疗方法.

科学领域:

营养科学营养科学
胃肠病学胃肠病学
生物化学生物化学

背景情况:

炎症性肠病 (IBD) 是一种慢性疾病,治疗选择有限.
蔓越的安托西亚宁具有抗氧化和抗炎性质.
铁亡是一种受调节的细胞死亡途径,与IBD病原发生有关.

研究的目的:

为了研究富含安东素的蔓越提取物对小鼠中硫酸 (DSS) 诱导的IBD的治疗效果.
阐明底层机制,重点关注铁亡调节和肠道微生物群调节.

主要方法:

从蔓越中提取和净化反素.
在小鼠中使用DSS诱导IBD.
评估IBD的严重程度,结肠长度,形态和生化标记 (铁,MDA,GSH).
分析与铁亡相关的基因,促炎性细胞因子和肠道微生物群组成.
使用抗生素和便微生物群移植 (FMT) 的干预研究.

主要成果:

蔓越提取物显著缓解了IBD症状,改善了结肠长度,并恢复了结肠形态.
提取物补充剂逆转了异常的铁和甲 (MDA) 水平,并恢复了谷氨酸 (GSH) 水平.
蔓越调节了与铁亡相关的基因,并减少了促炎细胞因子.
虽然蔓越影响了肠道微生物群,但它对IBD的有益影响在很大程度上独立于这些变化,如抗生素和FMT实验所示.

结论:

富含安东素的蔓越提取物显示出对IBD的显著治疗潜力.
主要机制涉及对结肠铁亡的调节.
有益的效果在很大程度上独立于实质性的肠道微生物群调节.

关键词:

安托氨酸是一种安托氨酸.蔓越是一种青.便微生物种群移植 (FMT) 方法铁化是铁化的一种.炎症性肠病 (IBD) 是一种炎症性肠病.

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