评估循环微量营养素和系统性红斑狼易感的因果关系:孟德尔的随机化研究
Shihui Huang1, Xuemei Wei2, Fang Qin1
1Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China.
Frontiers in nutrition
|August 20, 2024
概括
这项研究发现,更高的循环和铁水平可能会降低系统性红斑狼 (SLE) 的风险. 保持足够的水平可能有助于预防SLE的发展.
科学领域:
- 遗传学 遗传学 是一个
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 微量营养素水平与全身性红斑狼 (SLE) 风险之间存在相互矛盾的关联.
- 以前的研究已经产生了不一致的结果,关于SLE患者的微量营养素状况.
- 循环中的微量营养素与SLE风险之间的因果关系需要进一步澄清.
研究的目的:
- 调查循环微量营养素水平与患SLE的风险之间的潜在因果关系.
- 使用双样本的门德尔随机化 (MR) 分析来探索微量营养素和SLE之间的遗传联系.
- 提供关于微量营养素在SLE病变发生中的作用的强有力的证据.
主要方法:
- 采用两个样本的孟德尔随机化 (MR) 分析,使用56个单核酸多态 (SNP) 对于14个微量营养素作为仪器变量.
- 从IEU OpenGWAS数据库中获得了SLE总结统计数据.
- 使用MR-PRESSO,Cochrane的Q测试,MR-Egger拦截和留出一个分析进行了敏感性分析. 使用后勤回归,对NHANES III数据 (20,045名参与者) 进行了回顾性分析.
主要成果:
- 门德尔随机分析表明,循环 (OR:0.06) 和铁水平 (OR:0.63) 与SLE风险之间存在潜在的负相关性.
- 敏感性分析证实了这些发现的可靠性.
- 追溯分析显示,与对照人群相比,SLE患者的维生素D,血清总和血清铁水平显著降低.
结论:
- 遗传证据支持更高的循环水平在降低SLE风险方面起着保护作用.
- 适当的摄入量和维持足够的循环水平可能有助于降低SLE风险.
- 对SLE中和铁的特定机制进行进一步的研究是有必要的.
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