维生素D在中国骨质变异不完美的群体中的状况及其与骨代谢标志物和骨密度的相关性
Yunyi Jiang1, Yazhao Mei1, Yuan Tian1
1Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in nutrition
|August 20, 2024
概括
骨质发育不完善 (OI) 患者的维生素D缺乏率很高,水平与年龄,甲状腺激素和BMI负相关. 这凸显了在OI管理中评估维生素D状态的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 营养科学 营养科学
背景情况:
- 骨质变生不完美 (Osteogenesis imperfecta,简称OI) 是一种罕见的遗传疾病,其特征是骨脆弱.
- 在治疗前OI患者的基线维生素D水平没有得到充分记录.
- 了解维生素D的状况对于管理OI骨健康至关重要.
研究的目的:
- 评估一组骨质发育不完善 (OI) 患者的维生素D状况.
- 分析OI人口中不同年龄组的维生素D水平.
- 调查25-基维生素D (25(OH) D水平与与骨相关的因素之间的相关性.
主要方法:
- 从中国东部95名OI患者中收集了25...OH) D水平.
- 将患者分层分为子组:整体,18岁以下和18岁以上.
- 使用DXA测量身体指标,生化标志物和骨矿物密度 (BMD);用SPSS 26.0.0分析数据.
主要成果:
- 观察到的维生素D缺乏的高患病率:总体87.4%,<18岁的83.1%,<18岁的94.4% (<30 ng/mL).
- 较低的值 (<20 ng/mL) 也显示出高缺陷率:总体47.4%,<18年40.7%,>18年58.3%.
- 在25~OH) D和年龄,PTH,BMI和β-CTX (<18岁) 之间发现了负相关性;成年男性显示与OI严重程度的相关性.
结论:
- 显著的维生素D不足和缺乏在东中国的儿科,青少年和成人OI患者中很普遍.
- 基线25的OH) D水平与年龄,PTH,BMI和OI严重程度相关,但不是BMDZ-score.
- 研究结果为优化OI患者的维生素D状况的临床管理提供了关键的见解.
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