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微波辅助提取,分离和染色检测带有大麻,用于假定的禁用点测试

Killian C O'Connell¹, Mariana B Almeida^2,3, Renna L Nouwairi¹

¹Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA. kco4yh@virginia.edu.

|August 20, 2024

概括

一种新的离心微流体装置提供了快速的,自动化的假设药物查. 这项技术通过提供客观的现场识别非法物质,以最小的样本消耗来增强犯罪现场分析.

科学领域:

法医科学法医科学法医科学
分析化学分析化学
微流体学微流体学

背景情况:

假定的药物查对执法和法医实验室至关重要,但当前的化学实地测试是主观的,容易出错.
现有的微流体设备在克服传统现场测试的挑战方面取得了有限的成功,特别是在带样本方面.

研究的目的:

开发一种自动离心微流体装置,用于快速客观的假设药物查.
在单一的微流体平台上整合样品制备,分离和检测.

主要方法:

开发一个离心微流体装置,使用3D打印的子进行微波辅助提取.
在CIELAB中整合了色谱分离,使用四种微化学试验进行色素检测,以及客观图像分析.
概念验证演示使用与受控物质合的模拟大麻样本.

主要成果:

在分离和回收一个代表性的受控物质方面实现了93%的效率.
在使用等级集群分析的人工接样本中成功识别了三种非法药物 (海洛因,基基丁,可卡因).
证明了提取后的完全自动化,总分析时间低于8分钟,样品消耗最小化.

结论:

开发的微流体装置为假定药物查提供了经济有效,快速和客观的解决方案.
这项技术通过减少主观性和错误,显著改善了传统的化学实地测试.
该设备尽量减少样品的破坏,保存关键的法医证据进行进一步分析.

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