具有竞争事件的随机生存森林:基于分发的归算方法
Charlotte Behning1, Alexander Bigerl2, Marvin N Wright3,4,5
1Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.
Biometrical journal. Biometrische Zeitschrift
|August 20, 2024
概括
随机生存森林 (RSF) 现在可以使用归算策略来解释竞争风险. 这种方法改善了累积发病率函数 (CIF) 的估计,特别是当竞争事件很常见时.
科学领域:
- * 生物统计学
- * 机器学习 * 机器学习
- * 生存分析的分析.
背景情况:
- *随机生存森林 (RSF) 对复杂的时间到事件数据有价值.
- *在临床环境中常见的竞争事件,如果被视为审查,可能会偏见传统的RSF分析.
- *Fine & Gray的分发危险模型为竞争性风险提供了替代方案,但没有直接与RSF集成.
研究的目的:
- *将竞争的风险概念整合到随机生存森林 (RSF) 中.
- * 在RSF框架内开发和评估用于处理竞争事件的归算策略.
- * 在存在竞争性风险的情况下,改进累积发病率函数 (CIF) 的估计.
主要方法:
- * 开发了归算策略,适应离散时间分发危险模型权重.
- * 将这些归算方法集成到随机生存森林算法中.
- * 进行模拟以评估拟议方法的性能.
- *将该方法应用于慢性病的流行病学数据集.
主要成果:
- *在全球进行归算时,模拟显示了准确的CIF估计.
- * 建议的RSF方法有效地处理竞争事件,避免偏见将其视为审查.
- *即使事件率低或审查率高,该方法也表现出强的表现.
- *对慢性病数据集的分析产生了可信的预测因子-反应关系和CIF估计.
结论:
- *将竞争性风险建模集成到RSF中,为时间到事件分析提供了一个强大的方法.
- *开发的归算策略有效地提高了CIF估计的准确性.
- *这种增强的RSF方法对于临床和流行病学研究至关重要,在竞争事件普遍存在的地方.
- *忽视竞争事件可能导致生存分析的重大偏差.
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