激进囊切除术是否仍然在BCG不响应的非肌肉侵入性膀癌中发挥作用?
Leilei Xia1, Siamak Daneshmand
1Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Current opinion in urology
|August 20, 2024
概括
激进囊切除术 (RC) 仍然是巴塞勒斯卡尔梅特-盖林 (BCG) 无反应性非肌肉侵入性膀癌 (NMIBC) 的黄金标准. 虽然新型的膀节约疗法显示出希望,但由于有效性和持续时间有限,建议谨慎使用.
科学领域:
- 尿道瘤学 尿道瘤学
- 膀癌治疗方法 膀癌治疗方法
- 临床试验 临床试验
背景情况:
- 对Bacillus Calmette-Guérin (BCG) 无反应性非肌肉侵入性膀癌 (NMIBC) 的治疗环境已经发生了变化.
- 新型疗法和众多临床试验已经出现,促使人们重新评估治疗策略.
研究的目的:
- 审查根基囊切除术 (RC) 在BCG不响应NMIBC的管理中的当前作用.
- 评估最近在节约膀选择方面的进展的影响.
主要方法:
- 审查最近的食品和药物管理局 (FDA) 对新疗法的批准.
- 对BCG不反应的NMIBC进行临床试验数据的分析.
- 评估瘤控制,生活质量和治疗选择的成本效益.
主要成果:
- 目前FDA批准的新药用于BCG不响应的NMIBC具有严格的指示,低响应率和短时间的响应.
- 激进囊切除术 (RC) 提供卓越的瘤控制和可接受的生活质量.
- 对于BCG不响应的NMIBC,RC可能是最具成本效益的治疗选择.
结论:
- 尽管膀节约疗法取得了进展,但RC仍然是BCG不响应的NMIBC的黄金标准.
- 仔细选择患者和谨慎考虑节省膀的选择是必不可少的.
- 泌尿外科瘤学领域正在经历新的FDA批准和正在进行的临床试验的显著进展.
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