怀孕期间的SARS-CoV-2感染与妊娠期糖尿病之间的关联:基于索赔的队列研究
Oscar Rincón-Guevara1, Bailey Wallace2, Lyudmyla Kompaniyets3
1Inform and Disseminate Division, Office of Public Health Data, Surveillance and Technology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
概括
患有COVID-19的孕妇有更高的妊娠糖尿病 (GDM) 风险. 这种关联在早期的SARS-CoV-2变种时期特别被注意到,这强调了需要进一步研究的需要.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 孕期糖尿病 (GDM) 是怀孕期间的一个重大问题.
- 以前的研究表明,2019年新冠病毒病 (COVID-19) 和GDM之间存在潜在联系,但缺乏可靠的数据.
- 由于样本规模较小和没有对照组,证据有限.
研究的目的:
- 调查怀孕期间COVID-19感染与随后发展GDM的风险之间的关联.
- 量化GDM的相对风险和风险差异在怀孕和没有COVID-19诊断的孕妇中.
主要方法:
- 使用从2020年3月到2022年10月的医疗索赔数据进行了一项回顾性队列研究.
- 怀有COVID-19诊断的怀孕 (n=57,675) 与没有 (n=115,350) 的怀孕相匹配 1:2.
- 使用逻辑-二项式模型来估计GDM的相对风险和风险差异 (诊断≥23个妊娠周).
主要成果:
- 在怀孕期间的COVID-19患者中观察到温和但统计学上显著的GDM风险增加 (aRR=1.12).
- 这种关联在种族和种族群体中是一致的,包括非西班牙裔白人,非西班牙裔黑人和西班牙裔个人.
- 与Omicron相比,在delta变种前的时期,GDM风险较高,与delta变种期间没有显著差异.
结论:
- 怀孕期间的COVID-19与GDM风险的适度增加有关,特别明显的是基于索赔的数据.
- 在早期的SARS-CoV-2变种时期,这种关联更加明显.
- 建议使用系统测试进行进一步的研究,以确认这些发现.
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