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对于细胞去除DNA单链断裂的HPF1的可用性

Kristyna Hrychova1,2, Kamila Burdova1, Zuzana Polackova1

  • 1Laboratory of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague 4142 20, Czech Republic.

Nucleic acids research
|August 20, 2024
PubMed
概括

基因组PARylation Factor 1 (HPF1) 缺陷不会影响通过PARP1/2.2.进行的DNA单链断裂修复 (SSBR). 强大的多ADP-ribosylation和XRCC1招募维持SSBR能力,这表明HPF1对于这个过程是不可或缺的.

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