洗过的微生物移植改善了性结肠炎的血清维生素D水平
Hui Zhang1,2, Yuyan Xiao2, Quan Wen2,3
1Department of Nutrition, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Journal of gastroenterology and hepatology
|August 20, 2024
概括
洗微生物种移植 (WMT) 通过改变肠道细菌,改善了性结肠炎 (UC) 患者的维生素D (VD) 水平. 这表明肠道微生物群可能调节VD和UC活动之间的联系.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D缺乏与性结肠炎 (UC) 活动和肠道失调有关.
- 研究肠道微生物群对UC维生素D代谢的影响至关重要.
研究的目的:
- 探索洗微生物种移植 (WMT) 对UC患者维生素D代谢的影响.
- 为了确定WMT是否可以恢复UC患者的维生素D水平.
主要方法:
- 在121名UC患者和53名健康对照人群中比较了血清25-氧维生素D[25(OH) D]水平.
- 进行了一项非随机试验,将WMT (n=28) 与传统治疗 (5-ASA,n=10) 相比,持续了3个月.
- 评估了血清25(OH) D,便微生物群和维生素D受体 (VDR) 表达.
主要成果:
- 结核病患者的血清静脉疾病水平明显低于健康对照组 (P < 0.001).
- 在UC患者中,WMT显著增加了血清25(OH) D水平 (P=0.011) 和VDR表达 (P=0.026).
- 在WMT后增加的VD水平与Adlercreutzia equolifaciens,Ruminococcus obeum,Dorea正相关,与Escherichia负相关.
结论:
- 洗微生物种移植 (WMT) 有效地提高了UC患者的维生素D水平.
- WMT诱导了与改善维生素D状态相关的特定肠道微生物群变化.
- 肠道微生物群可能在调节维生素D和性结肠炎活动之间的关系方面发挥关键作用.
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