Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Synthetic Biology02:55

Synthetic Biology

4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.7K
Combinatorial Gene Control02:33

Combinatorial Gene Control

8.3K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Protecting cells at the genetic level and simulating unauthorized access via a biohackathon.

Science advances·2026
Same author

Identification of computationally designed skeletal and cardiac promoters with high specificity across AAV delivery routes.

BMC biotechnology·2026
Same author

Synthetic circuits for cell ratio control.

Nature·2026
Same author

Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.

Chemical reviews·2026
Same author

IWBDA 2023: Tools and Frameworks Take Flight.

ACS synthetic biology·2025
Same author

Improving engineered biological systems with electronics and microfluidics.

Nature biotechnology·2025
Same journal

Rational Design of Linalool Dehydratase-Isomerase Enables Efficient Conversion of Phytol to Neophytadiene.

ACS synthetic biology·2026
Same journal

<i>De Novo</i> Biosynthesis of Polyphyllin V in <i>Nicotiana benthamiana</i> through Pathway Reconstruction and UDP-Sugar Engineering.

ACS synthetic biology·2026
Same journal

Rapid and Continuous Directed Evolution in <i>Vibrio natriegens</i> Utilizing an <i>In Vivo</i> Hypermutation System.

ACS synthetic biology·2026
Same journal

Machine Learning for Microbial Cell Factories: Pathway Design, Enzyme Engineering, and Metabolic Regulation.

ACS synthetic biology·2026
Same journal

Microfluidics-Based Engineering of Molecular Self-Assembly and Manufacturing for Artificial Cell Systems.

ACS synthetic biology·2026
Same journal

Beyond Compartmentalization: Deciphering Reaction Kinetics in Liquid-Liquid Phase Separation for Rational Biotechnological Design.

ACS synthetic biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 16, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K

黄金:生物组合设计的框架

Nicholas Roehner1, James Roberts2,3, Andrei Lapets4

  • 1RTX BBN Technologies, Cambridge, Massachusetts 02138, United States.

ACS synthetic biology
|August 20, 2024
PubMed
概括
此摘要是机器生成的。

合成生物学家现在可以通过GOLDBAR优化DNA设计,这是一个比较生物设计规则的新框架. 这促进了合成生物学中的自动化分析和机器学习.

关键词:
生物设计是指生物设计.结合的工程结合的工程.设计自动化设计自动化遗传设计是一种遗传设计.机器学习是机器学习.正规的语法正规的语法

更多相关视频

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.4K
Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

13.4K

相关实验视频

Last Updated: Jun 16, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K
Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

12.4K
Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning
08:31

Rapid Assembly of Multi-Gene Constructs using Modular Golden Gate Cloning

Published on: February 5, 2021

13.4K

科学领域:

  • 合成生物学 合成生物学
  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 合成生物学依赖于组合图书馆来优化DNA设计.
  • 现有的设计框架缺乏用于自动化分析和机器学习的正式比较功能.
  • 大规模的生物设计空间需要先进的计算工具.

研究的目的:

  • 介绍GOLDBAR,一个组合设计框架.
  • 允许生物设计规则的正式比较和合并.
  • 促进合成生物学中的自动化分析和机器学习.

主要方法:

  • 开发了用于组合设计的GOLDBAR框架.
  • 应用GOLDBAR来分析转录逻辑电路和基因集群.
  • 展示了用于图案提取和推断的交叉和合并设计规则.

主要成果:

  • GOLDBAR完善了TetR同类转录逻辑电路的设计空间.
  • 使用GOLDBAR.验证了部分基因集群的组装.
  • 推断了用于rebeccamycin生物合成的新型基因集群.

结论:

  • GOLDBAR 增强了对生物设计的分析.
  • 该框架支持自动化分析和机器学习应用程序.
  • 在合成生物学中,GOLDBAR可以促进基于语法的机器学习.