系统性审查:与便免疫化学测试升高和便隐性血液阳性结果相关的死亡率
Francesca Ligori Malcolm1, Anjali K D S Yapa1, Zhen Yu Wong1
1Nottingham Colorectal Service, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK.
Alimentary pharmacology & therapeutics
|August 20, 2024
概括
便血红蛋白 (f-Hb) 水平升高与所有原因,非结肠直肠癌 (CRC) 和特定原因死亡率的增加有关. 需要进一步的人口研究来证实在有症状的个体中这种关联.
科学领域:
- 医学研究 医学研究
- 临床诊断 临床诊断 临床诊断
- 公共卫生 公共卫生
背景情况:
- 便血红蛋白 (f-Hb) 测试对于结直肠癌 (CRC) 查和诊断症状患者至关重要.
- 研究表明,高f-Hb水平与增加的死亡率之间存在相关性.
研究的目的:
- 评估高f-Hb与所有原因,非CRC和特定原因死亡率之间的关联.
- 分析阳性和阴性f-Hb测试后的死亡风险.
主要方法:
- 在Medline和Embase上进行了系统的文献搜索,寻找有关f-Hb测试 (FIT或gFOBT) 和死亡率的研究.
- 包括的研究报告了f-Hb测试后的死亡结果,主要关注全因死亡率.
主要成果:
- 十项研究,包括超过1460万个f-Hb结果,符合纳入标准.
- 升高的f-Hb显示所有原因,非CRC和特定原因死亡率的风险增加,包括心血管,消化和呼吸系统疾病.
- 全因死亡率的风险比为1.11至2.95,非CRC死亡率为1.09至2.79.
结论:
- 具有高f-Hb水平的个体表现出更高的全因,非CRC和特定原因死亡率.
- 建议进一步以人口为基础的研究,以探索在有症状的患者队列中这种关联.
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