在2023年,对中国的两个新型高度致病性复合NADC30类PRRSV菌株的基因组和致病性分析,在2023年
Hao Chang1,2,3,4, Xiaopeng Gao1,2,3, Yu Wu2
1Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Microbiology spectrum
|August 20, 2024
概括
两种新的重组猪生殖和呼吸系统综合征病毒 (PRRSVs),GD-7和GX-3,在小猪和母猪中显示病原性增加. 这些新型菌株强调了对不断发展的PRRSV进行持续监测和更新的控制策略的需要.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 猪病研究研究 猪病研究
背景情况:
- 猪生殖和呼吸系统综合征病毒 (PRRSV) 是高度可变和重组的,使免疫和控制工作复杂化.
- 自2013年以来,类似NADC30的PRRSV在中国占主导地位,由于新型重组菌株的病原性不同,对经济产生了重大影响.
研究的目的:
- 为了分离和描述新型重组PRRSV菌株.
- 评估这些新菌株在小猪和母猪中的致病性.
- 了解中国新出现的PRRSV复合物的流行病学影响.
主要方法:
- 从中国广东和广西分离出PRRSV菌株GD-7和GX-3.
- 全基因组测序,遗传学分析和重组分析.
- 在小猪和孕母猪中建立病原性模型,监测临床症状,死亡率和生殖参数.
主要成果:
- GD-7和GX-3被确定为NADC30PRRSV的新型重组菌株.
- 这两种菌株都在小猪中引起了显著的临床症状,GD-7的死亡率为33.3%.
- 在母猪中,GD-7导致了75%的存活率和堕胎,而GX-3导致了木乃伊化胎儿和死胎,表明了不同的致病特征.
结论:
- 新型重组PRRSV菌株GD-7和GX-3具有较高的致病性,对猪健康构成重大威胁.
- 这些发现强调,迫切需要加强对中国PRRSV的监测,快速检测和适应性控制策略.
- 对不断演变的PRRSV菌株的持续研究对于开发有效的免疫和疾病管理协议至关重要.
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