严重的多药性增加了老年人患有炎症性肠病住院的风险
Darren Drittel1, William Schreiber-Stainthorp2, Olivia Delau3
1Thomas Jefferson University-Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA.
The American journal of gastroenterology
|August 20, 2024
概括
多药在患有炎症性肠病 (IBD) 的老年人中很常见,增加了住院的风险. 对这个老龄化的患者群体来说,降低处方努力至关重要.
科学领域:
- 老年医学 老年医学
- 胃肠病学 胃肠病学
- 临床药房 临床药房
背景情况:
- 衰老的炎症性肠病 (IBD) 人口面临着不断上升的多药房率.
- 关于老年IBD患者的多药性患病率,风险因素和结果的数据有限.
研究的目的:
- 确定IBD的老年人中多药和潜在不适当药物 (PIM) 的患病率.
- 确定多药学的预测因素及其对一年住院率的影响.
主要方法:
- 对患有IBD的老年人进行回顾性单中心研究 (2011-2022年).
- 统计分析包括Wilcoxon签名的等级,McNemar,顺序逻辑回归和Cox比例危险模型.
主要成果:
- 74%的老年IBD成年人在首次诊断时有多种药物 (≥5种药物);42.6%使用PIMs.
- 严重多药性 (≥10种药物) 随着时间的推移从28.6%增加到38.6%.
- 多药性预测因素:年龄≥70,BMI≥30,之前的手术,并发症. 严重的多药和PIM使用增加了一年住院的风险.
结论:
- 严重的多药性在老年IBD患者中普遍存在并日益增加.
- 多药和PIM使用与更高的1年住院风险有关.
- 对这个人口群体来说,描述干预措施是必不可少的.
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