探索性结肠炎,结肠直肠癌和前列腺癌之间的关系
Yurie Kura1, Marco A De Velasco2, Kazuko Sakai1
1Department of Genome Biology, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Human cell
|August 20, 2024
概括
由性结肠炎 (UC) 和前列腺癌 (PCa) 引起的慢性系统性炎症可以增加结肠直肠癌 (CRC) 的风险. 这项研究揭示了PCa加剧了UC并促进了CRC的发展,突出了炎症.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 慢性系统性炎症,常见于性结肠炎 (UC) 和克罗恩病 (CD),与增加结肠直肠癌 (CRC) 风险有关.
- 新出现的证据表明UC和前列腺癌 (PCa) 之间存在联系,并可能存在PCa和CRC之间的联系,但这些联系需要进一步定义.
研究的目的:
- 研究前列腺癌 (PCa) 与慢性系统性炎症之间的关系,特别是其对性结肠炎 (UC) 和结肠直肠癌 (CRC) 发展的影响.
- 在临床前模型中阐明PCa相关炎症在恶化结肠炎和促进CRC中的作用.
主要方法:
- 使用了临床前小鼠模型,包括硫酸 (DSS) 诱导的大肠炎 (DSS-UC) 和DSS/亚基甲 (DSS/AOM) 诱导的CRC.
- 结合了野生类型和有条件的转基因小鼠PCa,以及免疫组织化学免疫分析.
主要成果:
- 前列腺癌 (PCa) 恶化了DSS诱导的UC严重程度,甚至在没有AOM的情况下导致了CRC的发展.
- 在没有PCa的小鼠中,DSS诱导的UC诱导了类似于增殖性炎症性缩的前列腺组织学变化.
- 患有PCa的小鼠在结肠中显示出增加的Gr1+髓质细胞,在DSS暴露后,这些细胞在结肠炎和瘤中进一步丰富.
结论:
- 提供了PCa例证的慢性系统性炎症与包括CRC在内的其他癌症的发展之间的联系的证据.
- 表明PCa诱导的全身炎症可能会产生有利于结肠炎和CRC进展的微环境.
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