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Updated: Jun 16, 2025

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基质基联体设计用于纳生物合成酶PhzFF的基质基联体设计

Janosch Baumgarten1,2,3, Philipp Schneider2,3, Marie Thiemann1,2,3

  • 1Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, Braunschweig, 38106, Germany.

ChemMedChem
|August 20, 2024
PubMed
概括

这项研究研究了来自Pseudomonas aeruginosa的酶PhzF作为新型抗生素策略的目标. 抑制PhzF可以减少病原体的毒性,而不会促进耐药性.

关键词:
抗病毒剂是一种抗病毒剂.药物发现 药物发现皮约亚酸盐是一种酸盐.这就是SBDDSBDD的意思.结构生物学是结构生物学.

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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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