潜在的肝毒性和polygoni multiflori caulis的成分含量之间的相关性分析
Ze-Ye Tan1, Gui Zhou1, Yi-Ming Feng1
1Department of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Journal of Asian natural products research
|August 20, 2024
概括
波利戈尼多花 (Polygoni Multiflori Caulis,简称PMC) 的不良反应经常被忽视. 本研究分析了来自不同地区的PMC中的肝毒成分,以确保更安全的临床使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 草药是一种草药.
- 毒理学 毒理学 毒理学
背景情况:
- 波利戈尼多花 (Polygoni Multiflori Caulis,简称PMC) 是一种在传统医学中广泛使用的草药.
- 记录了Polygoni Multiflori Radix (RPM) 的不良反应,但对PMC的潜在毒性了解较少.
- 确保草药的安全性需要了解活性成分和有毒成分的变化.
研究的目的:
- 研究来自不同地理来源的多多花 (PMC) 中存在的肝毒成分.
- 确定PMC的地理来源与其造成肝损伤的潜力之间的相关性.
- 为PMC的安全临床应用提供数据.
主要方法:
- 在PMC样本中对肝毒性化合物的定性分析.
- 鉴定出肝毒成分的定量评估.
- 在不同生产区域中比较化学特征.
主要成果:
- 在来自不同地区的PMC样本中观察到肝毒成分的类型和数量的变化.
- 特定的地理来源与某些肝毒性化合物的较高度有关.
- 该研究确定了导致PMC潜在肝毒性的关键化合物.
结论:
- 地理原产地显著影响了Polygoni Multiflori Caulis (PMC) 的肝毒性特征.
- 了解区域差异对于减轻与PMC相关的潜在不良反应至关重要.
- 这项研究为安全采购和PMC的临床使用提供了基础.
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Drug toxicity: Drug–Drug Interaction
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...


