异常的桃体微生物群调节了类风湿性关节炎的自身免疫反应
Jing Li1,2, Shenghui Li3,4, Jiayang Jin1,2
1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
JCI insight
|August 20, 2024
概括
类风湿性关节炎 (RA) 患者的桃体微生物群表现为失生症,具有致病性链球菌丰富和开始性链球菌缺乏. 这种不平衡有助于RA的发病和关节炎的发展.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 类风湿病学 类风湿病学
背景情况:
- 宫桃体是与微生物相互作用的关键免疫部位.
- 桃体炎症与诸如类风湿性关节炎 (RA) 等自身免疫性疾病有关.
- 桃体微生物群在RA病变发生过程中的作用尚不清楚.
研究的目的:
- 为了研究RA患者的桃体微生物群组成.
- 确定桃体微生物群对RA和关节炎发展的影响.
主要方法:
- 在RA患者和对照组中分析桃体微生物群.
- 使用原诱导性关节炎 (CIA) 的小鼠模型.
- 评估特定的链球菌物种和的作用.
主要成果:
- 关节炎患者表现出Streptococcus属的失生症,病原性物种增加 (S. pyogenes,S. dysgalactiae,S. agalactiae) 和开始性S. salivarius的减少.
- 在CIA模型中,致病性链球菌的殖民化加剧了关节炎的严重程度和自身免疫反应.
- 用致病性链球菌的免疫接种诱发了实验性关节炎.
- 在CIA小鼠中,S. salivarius治疗减轻了关节炎的进展,并降低了自身免疫反应的调节.
结论:
- 桃体微生物群失生症,特别是涉及链球菌,与类风湿性关节炎的发病有关.
- 致病性链球菌种有助于RA的发展,而开始性S. salivarius可能具有保护作用.
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