在健康的儿科队列中,对全转化胺,同型半氨酸和叶酸的连续参考间隔
Joel D Smith1, Vasiliki Karlaftis2,3, Stephen Hearps2
1Department of Laboratory Services, The Royal Children's Hospital, Parkville, VIC, Australia.
Annals of clinical biochemistry
|August 20, 2024
概括
确定儿童维生素B12和叶酸标志物的参考间隔至关重要. 这项研究为30天至18岁的健康儿童提供了holotranscobalamin,homocysteine和红细胞叶酸的连续参考间隔.
科学领域:
- 儿童营养学 儿童营养学
- 临床生物化学 临床生物化学
- 发育儿科 发育儿科
背景情况:
- 维生素B12和叶酸缺乏是儿童群体的重大问题.
- 评估健康儿童维生素B12和叶酸代谢的准确参考间隔 (RIs) 是有限的.
- 了解这些标志物的与年龄相关的变化对于正确的诊断至关重要.
研究的目的:
- 在儿童中为关键的维生素B12和叶酸代谢物建立连续的,年龄特定的参考间隔.
- 在整个童年和青春期中,描述全转化素,同型半氨酸和红细胞叶酸水平的动态变化.
- 为临床医生提供可靠的数据,以评估儿科患者的维生素B12和叶酸状态.
主要方法:
- 分析了378名30天至18岁以下健康儿童的血液样本.
- 连续的第95百分位基准区间的导出,用于全转甲胺,同氨酸和红细胞叶酸.
- 在不同发育阶段对标记物度的纵向评估.
主要成果:
- 整转甲胺水平在出生时最低,在幼儿时期增加,并在4-6岁后降低.
- 红细胞叶酸水平在生命早期最高,在成年后稳步下降.
- 婴儿时期的总同型半氨酸水平升高,在2岁时达到最低,然后在成年期增加.
结论:
- 对于30天至18岁以下的儿童,成功地建立了全转化素,同类半氨酸和红细胞叶酸的连续第95百分点参考间隔.
- 这些标志物在童年和青春期表现出显著的动态变化.
- 已建立的RI将帮助临床医生准确评估儿童和青少年的维生素B12和叶酸状况.
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